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Stress is said to be a source of aggravation of allergies!

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In a recent study, Japanese researchers indicate that stress and psychological tension are an aggravating factor for people subject to allergies. According to the study leaders, the increase in allergic reactions is linked to a particular hormone.

One culprit: corticotrophin

What if stress increases allergic reactions? Professor Mika Yamanaka-Takaichi of the University of Osaka (Japan) agrees, as evidenced by the publication of a study in the International Journal of Molecular Sciences March 9, 2021. The interested party explains in his report that in his daily practice, he meets many patients evoking a worsening of allergy symptoms due to psychological stress.

Mika Yamanaka-Takaichi recalls that any stressful situation is a source of corticotrophin (or adrenocorticotropic hormone – ACTH). However, the researcher’s work establishes a link between this hormone and the proliferation of mast cells. These are oval-shaped cells that are called upon when it comes to allergies in the nasal cavity. Thus, it is a question of a “mixture” contributing to the appearance of aggravated allergies.

This work could make it possible to better understand the origin of allergies, and therefore to find treatments capable of effectively overcoming it. Mika Yamanaka-Takaichi also mentioned the discovery of a promising therapeutic potential in certain candidates such as antalarmin. The latter is none other than a drug acting as an antagonist of CRH1, the corticotropin releasing hormone.

Credit: cenzi7 / Wikipedia

A major public health problem

According to an Inserm publication, 25 to 35% of the world’s population is affected by an allergic disease. Particularly common in children and young adults, anyone can suffer from it, with variations depending on the country and age. Two conditions are necessary, namely a genetic predisposition and of course, exposure to the allergenic substance.

The World Health Organization (WHO) ranks allergic diseases 4th in the world for chronic diseases. She considers them moreover as a major public health problem and evokes an impact on the quality of life, the loss of days of work or teaching, the cost of the treatments as well as the mortality in certain cases.

These allergies – especially seasonal – have a certain tendency to increase. Projections estimate that by 2050, half of the world’s population will be “allergic to something”, compared to less than 5% half a century ago.


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