During the first wave of the pandemic, Italy experienced a terrible massacre. It now lists 91,000 deaths due to the coronavirus. Its economy, the third largest in the European Union, is experiencing its worst crisis since World War II with an 8.9% drop in GDP in 2020 and heavy job losses. The populist adventure of the 5-Star Movement (M5S), or even of Matteo Salvini’s League, has devastated an already shattered political field. In such a critical health, political and economic situation, the advent of the government of Mario Draghi is a historic opportunity.